• Skip to primary navigation
  • Skip to main content
Rebiotix Logo

Rebiotix

Powerful Therapy Delivered

  • Home
  • About
    • Senior Management
    • Stool Donor Program
    • Careers and Employment
  • Our Therapy
    • The Human Microbiome
    • Microbiota Restoration Therapy
    • Clostridioides difficile Infection
    • The Future of Microbiome-Based Therapeutics
  • Clinical Trials
    • RBX2660 Clinical Trials
    • RBX7455 Clinical Evaluation
    • Physician-sponsored Studies
    • Patient Resources
    • Expanded Access Policy
  • Science
    • Congress Publications
    • Manuscripts and Whitepapers
    • Related Evidence
  • Media
    • Latest Press Releases
    • Frequently Asked Questions
    • “Rebiotix” in the News
    • Conferences
    • Media Tools
    • Presentations & Videos
    • Contacts
  • Contact Us
  • Show Search
Hide Search

Does the donor matter? Donor vs patient effects in the outcome of a next generation microbiota-based drug trial for recurrent Clostridium difficile infection

Arnab Ray*1, & Courtney Jones2

1Ochsner Clinic Foundation, New Orleans, LA, USA, 2Rebiotix Inc., Roseville, MN, USA

View the article at Future Medicine
Download this Clinical trial evaluation (1 MB)
March 17, 2016

Conclusions

Based on this analysis of the PUNCH CD study, the specific donor does not affect the outcomes achieved with administration of RBX2660 for recurrent CDI. The results suggest that outcomes are patient specific and it is not necessary to switch donors in order to achieve a cure if the first dose fails, although in some cases, a second dose may be necessary. To solidify these findings, a larger study with an expanded cohort of donors whose product is again randomized to the patient is currently underway. Additional research is also needed to provide more details on patient-specific factors that could potentially impact success or failure with this therapy. Such variables could include the retention of specific antibiotics in the intestinal tract before treatment, type of antibiotic regimen used prior to treatment, additional patient comorbidities not taken into account in this study and dosage timing.

Executive Summary

  • RBX2660 (microbiota suspension processed from unrelated donors) is an effective treatment for recurring CDI.
  • Success of RBX2660 treatment was not significantly impacted by donor or dose order.
  • Results suggest that outcomes are patient specific and it is not necessary to switch donors in order to achieve a cure if the first dose fails.

Keywords: Clostridium difficile infection, fecal microbiota transplant, fecal transplantation, FMT, FT, gut microbiota, RBX2660, stool donor

Microbiota Restoration Therapy Journal Articles Journal Articles

Interested in Becoming a Stool Donor? Learn More

Rebiotix

  • Copyright © 2022 Rebiotix, Inc.
  • A Ferring Company
  • Privacy Policy
  • Terms of Use
  • Sitemap
  • Contact Us