Are you suffering from C. diff ?
Clinical Study Now Enrolling at
University of Florida
using Fecal Transplant Therapy.
To see if you may qualify for the PUNCH CD3 clinical study
The PUNCH CD3 clinical study is open for adults with recurrent C. difficile infection that is only controlled by taking antibiotics. To speak with the clinical research coordinator at a study site in your area, please provide the following information:
Purpose of This C. diff Infection Clinical Study
PUNCH CD3 is a clinical study to evaluate the safety and efficacy of Rebiotix RBX2660 for the prevention of recurrent Clostridium difficile infection (CDI). This is the fourth investigational new drug clinical study evaluating RBX2660 for recurrent CDI. It is common for new drugs to undergo multiple studies before being approved by the Food and Drug Administration (FDA).
If you or someone you know has C. diff infection, contact Evan Waters at University of Florida to learn more.
Call or E-mail to Find Out if You May Participate
To learn more about participating in the PUNCH CD3 clinical study
What is RBX2660 and how does it prevent C. diff infection?
RBX2660 (microbiota suspension) is an investigational new drug that may prevent recurrent C. diff infection from returning. It is a biologic drug product prepared from live intestinal microbes, which are tiny living cells that can’t be seen without a microscope.
Everyone has "good" and "bad" microbes that live in their intestines. In healthy people, the good microbes keep the bad microbes in balance. There is scientific evidence that people who experience repeated episodes of C. diff may have an imbalance in their intestines that allows the "bad" microbes to grow more easily and overtake the good microbes, which causes severe diarrhea and other symptoms, and can be life-threatening.1
Some research studies have shown that putting a mix of good microbes into the intestines of someone infected with C. diff may relieve or stop C. diff.2,3 The purpose of this study is to learn about the safety of RBX2660, and determine whether it is effective at preventing recurrent C. diff infection.
Want More Information About the Study?
Further information is available:
- Rupnik M, Wilcox MH, Gerding DN. Clostridium difficile Infection: new developments in epidemiology and pathogenesis.Nat Rev Microbiol. 2009;7(7):526-536.
- van Nood E, Vrieze A, Nieuwdorp M, et al. Duodenal Infusion of donor feces for Recurrent Clostridium difficle. N Eng J Med 2013; 386(5):407-415.
- Gough E, Shaikh H, Manges AR. Systematic review of intestinal microbiota transplantation (fecal bacteriotherapy) for Recurrent Clostridium difficile infection. Clin Infect Dis. 2011 Nov;53(10):994-1002.
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